Started taking today. After the 1st Teaspoon, I could feel a difference!! I just took my 3rd teaspoon for the day and I feel good. I can feel it working. I used to take plain Ascorbic Acid , tons of it. But I don't think it was doing anything for my Adrenals. But you can definitely feel that this product is making it to the adrenals. Not stimulating or anything, just that 'back to health' feeling. I take a Tsp of LipoNano C with a Pantothenic Acid 250mg 3x's/day, and I feel the brain fog lift. Doesn't last all day that why you must multi dose throughout the day. I will be purchasing the 5 bottles. Highly Bio-Available. No Stomach Upset. No weird side effects. Excellent Vitamin C Product.