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CN31 - NEM Testing - MTHFR + COMT Test
CN31 - NEM Testing - MTHFR + COMT Test
List Price: $219.99
Our Price: $199.95

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For investigational purposes only. For interpretation and treatment consult your health care provider.

Buccal Swab testing for the assessment of MTHFR Mutation C677T, A1298C and COMT Mutation Val158Met.

What is MTHFR Gene Mutation?
MTHFR Gene mutation cannot process Vitamin B9 (folate) efficiently. Methylenetetrahydrofolate reductase (MTHFR) is an enzyme needed in the process of breaking down folate (Vitamin B9) and homocysteine for the body. In addition, individuals with mutations in the MTHFR gene often have elevated levels of homocysteine in their blood. This is related to a deficiency of folic acid (folate or Vitamin B9) and is connected to increased risk of heart disease. If the body is deficient of Vitamin B9, an important vitamin, the body is more at high risk to develop the life threating diseases and serious health conditions.

MTHFR may be associated with any one of the following health conditions:
  • Depression
  • Anxiety
  • Chronic Pain
  • Chronic Fatigue
  • Nerve Pain
  • Migraines
  • Elevated Homocysteine Levels
  • Fibromyalgia
  • Irritable Bowel Syndrome
  • Alzheimer Disease
  • Bipolar Disorder
  • Schizophrenia
  • Parkinson Disease
  • Stroke
  • Heart Disease
  • Multiple Miscarriages
  • Stillbirths and Other Birth Defects
  • Down syndrome
  • Autism

What are the common alleles of MTHFR Gene needs to be tested?
There are two most important alleles (C677T and A1298C) of the MTHFR gene are available to be tested in the laboratory.

Knowing the MTHFR mutation is important for making the best treatment plan to prevent diseases.
The COMT (catechol-O-methyltransferase) gene codes for the essential COMT enzyme that is involved in the inactivation of catecholamines such as dopamine and norepinephrine and catecholestrogens. Scientific research has demonstrated that a common mutation in the COMT locus results in the conversion of the amino acid valine to methionine at position 158, and causes a dramatic reduction in the enzyme’s ability to metabolize these neurotransmitters and catecholestrogens. The enzyme is notably active in the prefrontal cortex, or PFC; the area of the brain that gives rise to what we perceive as our personality, emotions, behavior inhibition, abstract thinking, and short-term memory. Val allele carriers have higher enzyme activity resulting in greater stress resiliency and lower dopamine levels, while Met allele carriers have lower enzyme activity resulting in reduced stress resiliency and higher dopamine levels, and heterozygous Val/Met allele carriers exhibit an intermediate enzyme activity.

This test is not available for residents of New York and Maryland.

Please note:
Test kits are non-refundable.

These statements have not been evaluated by the Food and Drug Administration (FDA). These products are not intended to diagnose, treat, cure, or prevent any diseases.

Do not use or rely upon the results from this and other similar direct-to-consumer tests to diagnose any medical disease as they have not been approved as medical tests.

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