Basic Chemistry
Phosphatidyl Serine when consumed in food, for example egg yolks, or in a capsule provides about 20% of active Phosphorylated Serine. Each 100mg of Phosphatidyl Serine yields about 20mg of active phosphorylated serine following consumption. The bulk of the weight is derived from 2 fatty acids
In the intestinal tract, the various enzymes clip off the fatty acids, predominantly the unsaturated fatty acids. These fatty acids are not reassembled in the body to the stump molecule, rather different fatty acids are attached by the body to replace RI and R2. The shaded glycerol molecule is very abundant in the body because it is found in all body fat and in dietary fats/oils in great abundance.
In brief, the Phosphatidyl Serine acts as a precursor molecule and is not the active form of this nutrient. In our tissues, the rate limiting step is the phosphorylation of the serine molecule. In contrast, Phosphorylated Serine (brand name, SERIPHOS®) provides the activated or Phosphorylated Serine in a chelate form of magnesium and calcium. In the local tissue, the Phosphorylated Serine is linked to glycerol and the appropriate fatty acids specific to each tissue, and is not linked to the fatty acids provided in the precursor Phosphatidyl Serine. Phosphorylated Serine (brand name, SERIPHOS®) is a pure product not derived from animal tissue. The serine is from vegetable sources and the phosphate is from a pure phosphate donor compound.
Other Ingredients:
Cellulose (plant fiber) and magnesium stearate (vegetable).
Ingredients per capsule:
Each capsule supplies 90 mg of serine phosphate as a calcium and magnesium derivative in a base of calcium and magnesium ethanolamine phosphate. Mineral nutrients provided are elemental Calcium 45 mg, Magnesium 45 mg and Phosphorous 190 mg.
Properties:
Clinically, Serine phosphate derivatives are better absorbed when ethanolamine salts are included. Serine phosphate derivatives are believed to help optimize brain neurotransmissions with specific reference to hypothalmic-pituitary area. It also exerts a beneficial effect on memory retention and recall by stimulating morphogenetic neuronal plasticity which delays or prevents age dependent neurotransmitter function deterioration or decline.
Clinical Applications & Indications:
Research indicates that serine phosphate derivatives can reverse hypothalmic-pituitary resistance to cortisol feedback in cases of cortisol hypersecretion. It is also indicated in conditions of memory deficit. Indicated in cognitive decline, senile dementia and mild cases of Alzheimer’s disease.
Restrictions:
Should not be given simultaneously with adrenergic agonists or alkaloid stimulants.
Dosage and Use:
A common daily dose used by many individuals is 1 capsule taken at least 20 minutes before or in between meal(s) with plenty of fluids. Seriphos® is best taken 1 hour before the time(s) of day when your cortisol levels are elevated. Feedback from users indicates that most individuals end up using it for a minimum of 3 months and a maximum of 9 months. In some instances, individuals start with 1 capsule per day and gradually increase dosage as directed.
Side Effects:
Some individuals may experience hyperactivity and/or mild insomnia. Elimination of the evening dose and restricting intake to morning and noon meals usually ameliorates this problem.
Contraindications & Precautions:
Seriphos should not be given to people using alkaloid stimulants or on adrenergic agonists Not recommended for use during pregnancy Not recommended for people with reduced kidney function or failure People with sensitive stomachs should take it with the meal, not before.
Special Instructions:
Store at room temperature below 25° C. Keep lid tightly closed.
For long term storage greater than 3 months, REFRIGERATE.
